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Iain McInnes discusses a 1994 paper by Ravinder Maini, Marc Feldmann and colleagues that showed a specific cytokine (tumour necrosis factor) could be targeted for therapeutic benefit in patients with rheumatoid arthritis.
Jennifer Gommerman discusses a 2008 paper by Sidonia Fagarasan and colleagues showing that isolated lymphoid follicles (ILFs) in the gut can function as inductive sites for the generation of IgA-producing plasma cells in the absence of T cell help.
Rémy Bosselut describes a 2001 paper by Jordan et al. showing that CD25+ regulatory T cells can be selected on self-peptides, which provided important insights into mechanisms of thymic tolerance.
