News & Comment

Ana Domingos describes a 1994 paper by Jeffrey Friedman and colleagues that identified the hormone leptin as the key regulator of body fat.

Connie Wong describes a 2003 paper by Andreas Meisel and colleagues linking post-stroke systemic immunosuppression to effects of the sympathetic nervous system on immune cells.

Prue Hart describes a 1983 paper by De Fabo and Noonan that identified urocanic acid as a major photoreceptor for ultraviolet radiation in the skin that induces systemic immunosuppression.

Christoph Hess describes a 1984 paper by Barry Marshall and Robin Warren that proposed that bacteria might be a key factor in chronic gastritis.

Betty Wu-Hsieh describes a 2013 paper by Gordon Brown and colleagues that showed fungal strain-specific interactions with the innate immune system.

Doreen Cantrell describes a 2005 paper by Graham Hardie and colleagues showing that Ca²⁺–calmodulin-dependent protein kinase kinases could phosphorylate and activate AMPK, which suggested a biochemical link between T cell receptor signalling and ATP production.

Mala Maini describes a 1996 paper by Frank Chisari and colleagues that showed CD8⁺ T cells can exert potent antiviral efficacy against hepatitis B virus without lysing infected cells, through the production of antiviral cytokines.

Ricardo Gazzinelli describes studies from the late 1980s and early 1990s that looked at the polarization of the recently described T_H1 cell and T_H2 cell subsets in the context of parasite infection.

Cristina Tato describes a 2013 study that used mass cytometry to investigate the receptor repertoire of natural killer (NK) cells, bringing to light new questions regarding NK cell maturation, functionality and memory potential.