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Ubiquitylation is an important regulatory process that controls numerous signalling pathways, including those that drive immune responses. As described in this Review, Pellino proteins are E3 ubiquitin ligases that regulate both innate and adaptive immune signalling pathways.
Here, the authors review the expression patterns and function of Fc receptors for IgG (FcγRs) on conventional dendritic cells (DCs), monocyte-derived DCs, plasmacytoid DCs and macrophages in the steady state and at sites of inflammation. They also discuss emerging concepts and areas that require further investigation.
In this Review, the authors describe the unique molecular and functional features of alveolar macrophages that distinguish these cells from other macrophage populations. They discuss how alveolar macrophages are able to shape both pro-inflammatory and tolerogenic immune responses in the lung in order to maintain health at this site.
