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Recent studies have identified potential factors and cellular environments that foster B-cell development in the bone marrow. As discussed, knowledge of such microenvironmental niches and of B-cell precursor populations has advanced our understanding of the spatiotemporal regulation of B-cell development.
Although T cells are derived from haematopoietic stem cells in the bone marrow, T-cell development occurs in the thymus. This Review describes recent data indicating that several cell populations in the bone marrow are able to populate the thymus and generate T cells.
Different pathogens have evolved distinct strategies to promote their survival in host cells. This Review describes the contribution of the endoplasmic reticulum to host defence and the mechanisms by which pathogens interacting with the endoplasmic reticulum subvert the host immune response.
This article describes the recent studies that elucidate the mechanism of action of the adaptor proteins SLP76 and SLP65. It details their crucial role in signalling by immunoreceptors and integrins, as well as their further unexpected roles in vascular development and leukaemia.
Members of the signalling lymphocytic activation molecule (SLAM) family of receptors associate with adaptor molecules of the SLAM-associated protein (SAP) family and have an important role in various aspects of innate and adaptive immune responses.
