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Kate Galloway highlights a paper by Kueh et al., who showed that the cell cycle indirectly influences concentrations of the transcription factor PU.1 to stabilize cell-fate trajectories in mice.
In this Journal Club, Hajk-Georg Drost highlights a recent study by Pavlopoulos et al. that organizes proteins at tree-of-life scale using massively parallel graph-based clustering.
Carl G. de Boer highlights a recent paper by Lim et al. on the importance low-affinity transcription factor-binding sites for determining organismal phenotypes.
Amnon Koren recalls two papers from 2001 and 2002 that laid the foundations for a new field by using microarrays to measure DNA replication timing across the genome.
Vincent Courdavault and Nicolas Papon highlight two articles in Nature, published in 2006 and 2013, that reported the biosynthesis of a complex natural plant product to treat malaria in engineered yeast.
Shinichi Morishita recalls a seminal publication by Weber and Myers, who in 1997 proposed a direct whole-genome shotgun sequencing approach to tackle the human genome.
The Farm Animal GTEx project introduces a new resource for pigs, in which they map genetic variation to differences in gene expression across thousands of samples.
A study in Nature Biotechnology reports a platform that combines lentivirus capabilities with antibody recognition for targeted cell delivery and genome editing.
Beer et al. use multiple complementary approaches to show that declining densities of the Tasmanian devil have had evolutionary effects on gene flow and selection in the subordinate predator, the spotted-tail quoll.
Mashaal Sohail reflects on a 2011 Nature study by Smillie et al., which analysed human microbiome data to show that microbial ecology, rather than phylogeny or geography, is a key driver of horizontal gene transfer.
Two papers in Nature Biotechnology report spatial transcriptomic methods for the simultaneous capture of host and microbial genes to study host–microorganism interactions.
Aashiq Kachroo highlights a recent paper by van Loggerenberg et al. that demonstrates the experimental power of ‘humanized yeast’ to gain insight into the genetic variants underlying disease.
