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Many methods are available for colorectal cancer (CRC) screening, ranging from noninvasive stool tests to endoscopy. In this Review, E. J. Kuipers et al. argue that the strength of any single test must be viewed in the context of a range of factors across the screening programme, including test characteristics, uptake, screenee autonomy, cost, endoscopy performance and long-term follow-up.
Late-stage distribution and bulky intraperitioneal disease are the hallmarks of ovarian cancer presentation, which is managed primarily by surgical resection and chemotherapy. However, advances in surgical resection objectives, alternative chemotherapy administration schedules, and novel therapeutics based on increasing knowledge of disease biology are making strides to improve outcomes. This Review covers all elements of the definition, treatment, and biology of ovarian cancer.
Combination strategies of molecular-targeted agents (MTAs) are being used in the hope of optimizing antitumour efficacy and to minimize the development of resistance, but very little effort is focused on molecular vulnerabilities of normal tissues. This Review discusses the main toxicities and the lack of tolerability of some common MTA combinations, and highlights what steps can be introduced for new preclinical testing paradigms for the assessment of chronic toxicities.
There is a general belief that paediatric palliative care should be provided only when no hope for the cure exists. This Review discusses how paediatric palliative care should be applied consistently and concurrently with other therapies regardless of the prognosis or disease stage, to ensure that the best possible care for children and their families is provided.
Patients with cancer frequently experience pain, which is considered to be the most-common and feared symptom of the disease. In most patients, this pain can be successfully relieved with judicious use of opioids. Unfortunately, there are a number of barriers to patients receiving adequate pain relief, which are outlined in this Review. Guidelines and strategies to improve pain relief for patients with cancer are also outlined.
