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Peripartum cardiomyopathy (PPCM) is a rare form of heart failure that presents in late pregnancy or early in the postpartum period. In this Review, Hoes and colleagues discuss the known risk factors for PPCM, including genetic variants and pre-eclampsia, and describe the potential pathogenic mechanisms underlying the development of PPCM such as disrupted metabolic homeostasis in the heart owing to pregnancy-induced hormone fluctuations.
Peripheral artery disease (PAD) is a growing global public health problem owing to its high and rising prevalence and association with adverse outcomes. In this Review, Golledge summarizes the epidemiology, presentation, outcomes, pathophysiology and current treatment of PAD, and outlines ongoing research into new medical treatments.
In this Review, von Haehling and colleagues provide clinicians with practical recommendations for patients with heart failure who plan to travel, including guidelines for pre-travel risk assessment and special considerations for patients who have undergone recent surgery or have a cardiac implantable electronic device.
In this Review, Raitakari and colleagues discuss the importance of initiating the prevention of atherosclerosis in early life and summarize the major paediatric programmes for the prevention of atherosclerotic cardiovascular disease.
In this Review, Frangogiannis summarizes the current evidence on the role of TGFβ signalling in myocardial diseases, focusing on TGFβ functions in cardiac pathophysiology and its cellular actions and molecular effectors, and discusses challenges and opportunities for therapeutic interventions targeting the TGFβ system in heart disease.
