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In the first section of this two-part Review, Dr Sweeny and colleagues explore the phenomenon of 'resistance' to antiplatelet drug therapy. They discuss the various factors influencing the patient's response to these drugs, and examine the link between laboratory-assessed nonresposiveness and clinical outcome.
Ventricular remodeling occurs over the weeks and months after myocardial infarction, and, therefore, provides a large temporal therapeutic window. In this Review, Dr Dorn examines recent developments in pharmacological treatment of ventricular remodeling in preclinical models of myocardial infarction.
Current treatment guidelines recommend exercise training in patients with heart failure classified as NYHA functional class II and III. This Review focuses on current knowledge of mechanisms by which progressive and moderate exercise training can have sustained beneficial effects on these patients.
Proteinuria often precedes any detectable decline in renal filtration function and is a strong and independent predictor of increased risk for all-cause and cardiovascular mortality. In this Review, Dr Agrawal and colleagues examine potential pathophysiologic mechanisms to explain simultaneous renal and cardiac disease, as well as therapeutic strategies for amelioration of proteinuria.
Understanding the mechanism by which hypertension induces vascular disease is important for the prevention of this adverse process. In this Review, Dr Rabkin examines the data on interleukin 18 involvement in the pathogenesis of hypertension-induced vascular disease.
Imaging of atheromatous plaques can provide important information about the natural history and progression of atherosclerotic disease and can help inform treatment decisions. Here, Umar Sadat and colleagues review various noninvasive imaging techniques for the clinical assessment of carotid plaques, including radionuclide imaging, CT, and MRI.
Renal artery stenosis (RAS) is common among patients with atherosclerosis. In this Review, Drs White and Olin outline the clinical problem of atherosclerotic RAS and its diagnosis, and critically assess treatment options and strategies to improve patient outcomes.
