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Terpene cyclization inside the resorcin[4]arene capsule
Hexameric capsules that self-assemble from resorcin[4]arene are shown in this rendered image. Luminous oxygen and hydrogen atoms highlight the hydrogen bond network holding the assemblies together. In the foreground, the capsule is open, revealing its content: a cyclized presilphiperfolanol molecule. See Cornu et al.
Image : Ivan Cornu, University of Basel. Cover design: S. Whitham.
Tail-to-head terpene cyclization is an essential reaction for terpene synthesis, but it is difficult to achieve without an enzyme. This protocol describes the preparation and use of a hexameric resorcin[4]arene capsule as an artificial enzyme.
Obtaining large, uniform crystals of polymer materials, including covalent organic frameworks, is challenging. This protocol describes a fast, effective approach to making crystalline two- and three-dimensional covalent organic frameworks using supercritical CO2 as the solvent.
This protocol for the spatiotemporal control of RNA activity uses LicV, a synthetic, photoswitchable RNA-binding protein (RBP) that can bind to a specific RNA sequence in response to blue light irradiation, and provides an efficient and generalizable strategy for engineering photoswitchable RBPs.
The recently available 28.2 Tesla nuclear magnetic resonance spectrometers (1.2 GHz 1H frequency) can be used to characterize highly flexible proteins and protein regions. This protocol explains how to setup 13C nuclear magnetic resonance experiments to achieve optimal results.
The detailed design and fabrication of small-scale magnetic soft-bodied robots with multimodal locomotion capability, including the processes required for locomotion control and optimization.
Single-cell multiple displacement amplification with the variant caller SCcaller ensures high-fidelity, quantitative analysis of single-nucleotide variations and small insertions and deletions.
Two-dimensional protein films, prepared via amyloid-like aggregation, can be made with nano- to meter-scale dimensions and features such as high interface adhesion, as well as tunable antibacterial, biomineralization and antifouling activity.
An automated workflow for culturing human induced pluripotent stem cells expressing fluorescently tagged proteins, and seeding them on 96-well optical-grade, glass-bottom plates for high-quality, live-cell three-dimensional microscopy on a large scale.