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Peptidoglycan biosynthesis is regulated by a feedback mechanism preventing the pathway from sequestering essential lipid carriers used to assemble and transport surface glycan subunits.
GWAS in difficult-to-recruit populations identifies variants associated with Lassa fever outcome and susceptibility at loci proximal to LIF, GRM7 and LARGE1.
Rhesus macaques are susceptible to oral challenge of human noroviruses and can be used as a model to recapitulate infection and adaptive immune responses in humans.
A trait-based approach harnesses the vast amount of microbial genomic data and enables integration with biogeochemical models, predicting soil microbial ecology and physiology without the need for cultures.
Automated and scalable designation of virus lineages based on a heuristic approach can help to determine and curate virus lineages from large genomic datasets and inform nomenclature.
Tc toxins of Yersinia entomophaga are assembled only in a subpopulation of cells, followed by a suicide mechanism that results in the release of the toxins.
The gut virome is altered in a mouse model of chronic stress and is associated with changes in behavioural and immune response, which can be restored using faecal virome transfer.
Isotope tracing, kinetics and transcriptomics show how members of the four AOM lineages employ different nitrogen use strategies that minimize competition for nitrogen substrates.
Ocean viral proteome annotations are expanded by a machine learning approach that is not reliant on sequence homology and can annotate sequences not homologous to those seen in training.
Radiolabel-based bioassays, nanoSIMs, metagenomics and lipidomics conducted on samples collected along the East Pacific Rise show higher than expected chemosynthetic microbial activity on inactive vents.
Genomic evidence reveals that Mycobacterium ulcerans recovered from Aedes notoscriptus mosquitoes are genetically identical to bacteria from possums and humans, implicating mosquitoes as a vector for Buruli’s ulcer transmission in southeastern Australia.
A specialized subpopulation of Yersinia entomophaga cells uses a RoeA-regulated, temperature- and pH-dependent type 10 secretion system to mediate lytic Tc toxin release.
Prokaryotic RNA viruses recovered from hot springs in Japan using fragmented and primer-ligated dsRNA sequencing form divergent clades in the Riboviria branch of RNA viruses.
The gut commensal Christensenalla minuta produces a previously undescribed class of secondary bile acids that counteract features of metabolic disease and are depleted in patients with type 2 diabetes.