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Transcriptional interactions between co-existing microorganisms from stool samples revealed enriched interactions involved in H2 and CO2 homeostasis, butyrate biosynthesis, ABC transporters, flagella assembly, bacterial chemotaxis and metabolism.
Intracellular microsporidian parasites can restructure host cells to induce fusion with neighbouring cells, which enables cell-to-cell spread independent of spore formation.
That the Zika virus epidemic could result in infections of 1.65 million childbearing women and 93.4 million people suggests an approach that combines epidemiological theory with data on seroprevalence and drivers of transmission to make location-specific projections.
The mouse gut microbiota produce free d-amino acids and induce the production of d-amino acid oxidase by intestinal epithelial cells. Oxidative deamination of d-amino acids yields H2O2, which protects the mucosa from Vibrio cholerae.
In Vibrio cholerae, which has two chromosomes, Chr2 rather than Chr1 harbours binding motifs for an inhibitor of Z-ring formation. This helps accurately position the divisome at mid-cell and postpones its assembly to the very end of the cell cycle.
Genomic analysis of global Babesia microti isolates reveals a population segregated into distinct geographic lineages and identifies variants in drug-binding regions of cytochrome b and ribosomal protein subunit L4 that are associated with relapsing disease.
The human cytomegalovirus (HCMV) gHgLgO trimer binds with high affinity through the gO subunit to platelet-derived growth factor-α receptor (PDGFRα), which is expressed on fibroblasts but not on epithelial cells.
Pelagibacter simultaneously produces the biogenic gases methanethiol and dimethyl sulfide from dimethylsulfoniopropionate, regulated by a kinetic switch that balances DMSP allocation between each pathway depending on cellular sulfur demands.
The translocation assembly module (TAM) of Escherichia coli functions together with the BAM complex to mediate the rapid assembly of usher proteins, the molecular platform important for the biogenesis of bacterial fimbriae.
Single-cell measurements of metabolic activities using NanoSIMS reveals that substrate limitation increases phenotypic heterogeneity in Klebsiella oxytoca metabolism, which allows cells to cope with nutrient fluctuations.
Bacteria enriched from surface and plume waters of the 2010 Deepwater Horizon oil spill show that the combined capabilities of community-wide hydrocarbon degradation is greater than its individual components.
Using a bacteriophage infection model that allows physical separation between growth and mutagenesis, this study provides support for the natural selection of random mutations as a basis for adaptation to stress.
Using Volta phase plate cryo-electron tomography, influenza virus haemagluttinin is shown to induce two independent pathways of viral membrane fusion, through lipidic junctions or through a fusion pore.