News & Comment

A microfluidic device tracks the lineage and transcriptional profiles of individual cells.

Scientists can maintain orthogonal translation systems over many bacterial generations by making an essential gene depend on a nonstandard amino acid.

A nanopore built from DNA allows the controlled and selective transport of organic molecules across a lipid membrane.

The use of photoswitchable fluorescent proteins in STED nanoscopy enables higher-contrast imaging with dramatically reduced photobleaching.

An unsupervised approach with high predictive power provides a single measure of functional importance for each variant in the human genome.

A combination of flexible imaging and computational methods opens new views into the dynamics of activity across large populations of neurons.

Researchers monitor cotranslational protein folding in real time.

Absolute levels of the Escherichia coli proteome measured under 22 different conditions represent a valuable resource.

Patch-seq integrates functional and molecular properties of single neurons to tackle heterogeneity in the brain.

Laboratory tests show that gene drives could obliterate wild mosquito populations carrying the malaria parasite, or make them resistant to its transmission.

Small chemical tweaks during tissue preparation make a big difference for imaging thick, complex biological samples.