News & Comment

Researchers in three independent laboratories develop nanoscale devices for network-level electrophysiology.

Engineered firefly enzymes use new substrates and emit at redder wavelengths.

Rationally designed RNAs that work with the bacterial immune response allow targeted gene silencing in prokaryotes.

An electronic circuit enables analysis of dynamic processivity of single molecules.

Structure of modular DNA-recognition domain is revealed.

The integration of protein-protein interaction networks with structural information about the interacting protein partners creates a three-dimensional scaffold on which are mapped mutations involved in human disease.

Researchers develop a genetic method for degradation of GFP protein fusions in cells and living flies.

A fluorescent protein fusion reports levels of the plant hormone auxin by succumbing to its degradation signal.

Arabinosyl nucleosides are an addition to the toolkit of DNA-labeling methods.

Exonuclease digestion of immunoprecipitated chromatin sharpens protein binding peaks and improves signal.

An in vitro RNA-labeling technique with single-molecule resolution offers a look into the kinetics and the location of splicing.

The use of a photoswitchable fluorescent protein allows nonlinear structured-illumination microscopy of cellular structures at 50 nanometer resolution.

Microscopic optical devices make their way into living cells.

Two independent research groups derive haploid mouse embryonic stem cells and propose their use for genetic screens.

Different ratios of reprogramming factors affect the epigenetic state of cells.