News & Comment

Single-molecule imaging helps researchers to begin a biography for clathrin-coated vesicles.

Bacterial proteins are used to rewire signaling pathways in yeast and mammalian cells.

A 'neutralizer displacement assay' provides a general platform for electrochemistry-based sensing of any class of analyte molecule.

Researchers describe an approach to zero in on post-translational modifications likely to have important regulatory functions.

Acoustic tweezers nudge cells or particles with sound waves.

Using a special nanochannel chip, genome maps can be constructed from single DNA molecules in any laboratory.

Examining how proteins from tumor viruses affect their cellular targets helps researchers zero in on the human genes that drive cancer.

A computer model of a bacterium accounts for gene function and predicts unexpected emergent properties.

Researchers continue to improve the performance of the atomic force microscope.

Tracking single molecules in real time reveals the hidden dynamics of translational initiation.

Tandem fluorescent protein timers allow measurements of both protein turnover and trafficking in the cell.

Codifferentiating human pluripotent stem cells along neural and endothelial lineages provides cues to efficiently generate blood-brain barrier endothelial cells.

Lifespan in nematodes is markedly extended when an unusual combination of aging components is engineered into their genome.

Recruiting chromatin modifiers to a specific locus allows the regulation of heterochromatin formation in living cells.

Researchers design a simple 'shake & bake' method for the assembly of complex nanostructures from interlocking DNA tiles.

An optical compensation technique enables deeper, crisper two-photon microscopy.

Enzymatic glycosylation and oxidation of methylated DNA together with high-throughput sequencing allows genome-wide base-resolution of 5-hydroxymethyl cytosine distribution.

Human embryonic stem cells are screened with a panel of antibodies to identify cellular subsets that may correspond to early human progenitor cell populations.

A surprising hydrogel formation promises insight on prions and RNA transport.

A nanofluidic device can sort single DNA molecules based on their epigenetic marks.