This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Using mice from different breeding sites fails to improve replicability of results from single-laboratory studies
Lab Animal Open Access 27 December 2023
-
Controlling the uncontrolled variation in the diet induced obese mouse by microbiomic characterization
Scientific Reports Open Access 12 August 2022
-
Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis
BMC Biology Open Access 13 January 2022
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fnmeth0310-167/MediaObjects/41592_2010_Article_BFnmeth0310167_Fig1_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fnmeth0310-167/MediaObjects/41592_2010_Article_BFnmeth0310167_Fig2_HTML.jpg)
References
Richter, S.H., Garner, J.P. & Würbel, H. Nat. Methods 6, 257–261 (2009).
Beynen, A.C., Gärtner, K. & van Zutphen, L.F.M. in Principles of Laboratory Animal Science 2nd edn. (eds., van Zutphen, L.F.M., Baumans, V. & Beynen, A.C.) 103–110 (Elsevier, Amsterdam, 2003).
Würbel, H. Nat. Genet. 26, 263 (2000).
Crabbe, J.C., Wahlsten, D. & Dudek, B.C. Science 284, 1670–1672 (1999).
Paylor, R. Nat. Methods 6, 253–254 (2009).
Larkin, J.E., Frank, B.C., Gavras, H. & Quackenbush, J. Nat. Methods 2, 337–343 (2005).
Acknowledgements
This study was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Supplementary Text and Figures
Supplementary Figures 1–4, Supplementary Methods (PDF 447 kb)
Rights and permissions
About this article
Cite this article
Richter, S., Garner, J., Auer, C. et al. Systematic variation improves reproducibility of animal experiments. Nat Methods 7, 167–168 (2010). https://doi.org/10.1038/nmeth0310-167
Issue Date:
DOI: https://doi.org/10.1038/nmeth0310-167
This article is cited by
-
Using mice from different breeding sites fails to improve replicability of results from single-laboratory studies
Lab Animal (2024)
-
Understanding Individual Subject Differences through Large Behavioral Datasets: Analytical and Statistical Considerations
Perspectives on Behavior Science (2024)
-
Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis
BMC Biology (2022)
-
Controlling the uncontrolled variation in the diet induced obese mouse by microbiomic characterization
Scientific Reports (2022)
-
Autism-associated biomarkers: test–retest reliability and relationship to quantitative social trait variation in rhesus monkeys
Molecular Autism (2021)