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The multi-trait set test (mtSet) is an efficient mixed-model method that enables genome-wide association tests for large cohorts and multiple quantitative traits using sets of variants to improve power and sensitivity, while addressing confounding due to population structure.
An analytical method, with accompanying software, is described for improved fidelity in traction force microscopy and is used to measure forces at emerging focal adhesions at high resolution.
A human-liver chimeric mouse supports the growth of recombinant Plasmodium falciparum progeny, enabling easy analysis of genetic crosses between parasite strains.
Bioluminescence resonance energy transfer, from the substrate of a luciferase fused with a G protein–coupled receptor to a fluorescent dye covalently linked to a receptor ligand, allows the profiling of ligand affinity and binding kinetics.
This paper shows that microfluidic perfusion frequency can be optimized to improve the differentiation of human pluripotent stem cells along different lineages, and uses this principle to achieve functional hPSC differentiation directly on a chip.
A robotic system is described that uses machine vision guidance to pick, manipulate, inspect and dissect individual flies, enabling large-scale and automated approaches to the analysis of morphology, behavior and neural dynamics.
Dynamic nuclear polarization–based solid-state nuclear magnetic resonance spectroscopyis applied to study the structure of a large bacterial membrane protein complex in its cellular environment.
Primed conversion of proteins such as Dendra2 confines photoconversion to a limited 3Dvolume through a sequential absorption process relying on illumination with two separate low-intensity lasers and enables precise targeting of single cells.
Tissues from multicellular organisms can be imaged by cryo-electron tomography using an optimized combination of vitrification, milling and application of fiducial markers.
Light-sheet microscopy using a single objective and micromirrors to orient the light sheet enables high- and super-resolution imaging of cells and embryos on a standard microscope.
CONSERTING detects somatic copy-number alterations from whole-genome sequence data with high accuracy and sensitivity and identifies breakpoints even in heterogeneous or impure tumors.
Kohinoor is a fast- and positively switching fluorescent protein with high photostability over many photoswitching cycles. Its improved photophysical properties enable nanoscopy with low phototoxicity and allow use of a simplified RESOLFT setup.
Targeted enrichment and duplex sequencing yield extremely efficient, accurate and sensitive sequencing of rare subclonal mutations in small genomic target regions.
A new metric, Correlation Map (CorMap), which provides a goodness-of-fit test for comparing one-dimensional spectra without the need of estimating experimental errors, is developed and applied to evaluate small-angle X-ray scattering (SAXS) data from biological macromolecules.
Measuring the expression of a GFP-based capacity monitor in E. coli enables assessment of the burden heterologous gene expression exerts on the cell and allows for forward design of constructs with improved growth.
Photoacoustic microscopy is a hybrid imaging technology based on the conversion of absorbed light into ultrasound emission. A single-wavelength pulse-width-based method allows fast functional imaging of the brain.