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Volume 13 Issue 8, August 2007

In this issue, Richard Lee and colleagues use a genetic fate-mapping approach to implicate the contribution of stem cells to heart tissue (p 970). Mouse cardiomyoctyes were irreversibly marked with green fluorescence protein (GFP), and then the mice were allowed to age normally or had their hearts injured. After injury—but not after normal aging—the percentage of GFP-positive cardiomyocytes dropped, implying that new cardiomyocytes were derived from stem cells. The cover image shows cardiomyocytes harvested 3 months after injury (GFP, green; β-galactosidase, red; 4',6-diamidino-2-phenylindole (DAPI), blue).

Volume 13 Issue 8

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Editorial

  • Good reviewers underpin the quality of a journal. At Nature Medicine, what do we seek in our reviewers? And how do we retain the best in the face of the plethora of requests from an increasing number of journals?

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  • A genetic lineage-tracing study provides evidence that adult progenitor cells repopulate the cardiomyocyte pool in diseased hearts, but not during normal aging (pages 970–974). These stem cells could become the basis for innovative ways to treat or prevent heart failure.

    • Charles E Murry
    News & Views

  • Mice deficient for the cytokine interleukin-15 are unexpectedly protected from sepsis. Orinska and colleagues show that interleukin-15 signals intracellularly in mast cells and limits their recruitment of neutrophils to clear the infection (pages 927–934).

    • Peter A Ward
    News & Views

  • Rosacea is a common skin disorder marked by chronic inflammation and vascular abnormalities. Two new features of the skin lesions have been identified: elevated levels of cathelicidin antimicrobial peptides and of a related serine protease. These molecules of innate immunity may represent key elements of pathogenesis, as well as new targets for effective therapies (pages 975–981).

    • Charles L Bevins
    • Fu-Tong Liu
    News & Views

  • The role of microbial pathogens in human cancer is a fertile area of research, with important implications for treatment. Two pathogens implicated in Burkitt's lymphoma have now been shown to directly interact with one another.

    • David A Thorley-Lawson
    • Karen A Duca
    News & Views

  • Cyclin-dependent kinase 5, a serine/threonine kinase, contributes to neurodegeneration in Parkinson's disease. This kinase is now shown to phosphorylate peroxiredoxin-2, inactivating it, and thereby sensitizing neurons to the deleterious effects of parkinsonian toxins.

    • Serge Przedborski
    News & Views

  • Contemporary M1 strains of Streptococcus pyogenes have acquired a DNase gene that improves the virulence of the bacterium, but its expression is repressed by the CovRS regulatory system. Walker et al. report that the bacteria are under selective pressure to mutate the covRS locus to maintain DNase expression for invasive infection (pages 982–986).

    • Claire Turner
    • Shiranee Sriskandan
    News & Views
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