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Volume 12 Issue 7, July 2006

On page 835, Loukas and colleagues show that individuals resistant to schistosomal infection make immune responses to the schistosomal tetraspanin TSP2. In mice, the authors show that TSP2 is a promising antischistosomal vaccine candidate, reducing adult worm burdens and liver and fecal egg counts. The cover image shows paired adult-stage Schistosoma mansoni blood flukes. The larger male worm is carrying the female worm in his gynecophoral canal. This is a permanent state of mating and is how adult worms are usually found in vivo. Photo courtesy of Malcolm Jones, Queensland Institute of Medical Research, Australia.

Editorial

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News

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Correspondence

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Book Review

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News & Views

  • Young children are particularly susceptible to seizures induced by high fever. Experiments in rats suggest that changes in brain pH might be to blame (pages 817823).

    • Ricardo Tapia
    News & Views
  • Fungal cell-wall polymers are potent stimulators of immune responses. New findings reveal that fungi shield inflammatory cell-wall polysaccharides from immune recognition, a process that is disrupted by an antifungal compound.

    • Tobias M Hohl
    • Eric G Pamer
    News & Views
  • Findings in mice suggest that treatment with VEGF inhibitors prompts the upregulation of erythropoietin (Epo), a powerful cytokine and regulator of blood cell development. Could Epo be dulling the therapeutic effects of VEGF inhibition?

    • Christian Fischer
    • Peter Carmeliet
    • Edward M Conway
    News & Views
  • Animal models of schizophrenia are incomplete, and human brain tissue has been difficult to study. Results from postmortem human tissue begin to overcome these hurdles and find a role for modulation of NMDA type glutamate receptors (pages 824828).

    • Gerald D Fischbach
    News & Views
  • A metagenomic analysis of the microbes in the human gut reveals their diversity and just how interdependent we are on them. Together with our microbes we are a human-bacterial superorganism with immense metabolic diversity and capacity.

    • Inna Sekirov
    • B Brett Finlay
    News & Views
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Introduction

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News

  • Is there a conspiracy afoot to keep one theory dominant in Alzheimer disease research? Maybe not, but as Apoorva Mandavilli discovers, it may still be high time for new ideas.

    • Apoorva Mandavilli
    News
  • How reliable are mouse models of Alzheimer disease?

    • Apoorva Mandavilli
    News
  • Between lively banter and public debates, Virginia Lee and John Trojanowski have challenged Alzheimer disease researchers to look beyond the usual suspects. What's the secret of their success?

    • Meredith Wadman
    News
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News & Views

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Commentary

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Market Analysis

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Brief Communication

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Article

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Letter

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Technical Report

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Erratum

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Corrigendum

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Focus

  • In the same spirit as our metabolic syndrome focus, a close look at the papers that have had the most influence on the Alzheimer community, and an analysis of the relevant drug market and funding priorities.

    Focus
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