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Plasmodium falciparum parasites survive the dry season by accepting increased clearance rates through the host spleen, which leads to a persistent lower-level infection.
Genome sequencing of patients with sporadic congenital hydrocephalus reveals mutations of large effect size indicative of a developmental origin for the disease.
Understanding the risk of reinfection with SARS-CoV-2 in exposed cohorts provides an avenue to understanding the path to protection against SARS-CoV-2 for vaccine development.
The Zero Childhood Cancer Program’s multi-platform sequencing approach identified molecular alterations in 94% of a cohort of 247 pediatric patients with high-risk cancers, which has enabled more-precise diagnoses and alternative therapeutic recommendations.
A metabolic study comparing people who lost weight through dieting or through bariatric surgery shows that the effects on diabetes are due to weight loss.
Combining organoids and decellularized intestinal scaffolds generates durable hybrid intestines that will open up new avenues for the regenerative treatment of patients with intestinal failure.
An increase in cannabis use is inevitable, and the spread of its legalization will probably result in increasing use during pregnancy. A study from Canada uses real-world data to quantify the cognitive effects on offspring of in utero cannabis exposure.
Single-cell RNA sequencing across the menstrual cycle reveals human endometrial cell–specific preparation for embryo implantation, menstruation and tissue renewal.
Vaccines directed against SARS-CoV-2 have been administered to healthy volunteers and have been shown to stimulate a brisk humoral and cellular immune response. All vaccines were generally well tolerated with mostly mild to moderate local and systemic reactions.
Modeling the impact of COVID-19-mitigation strategies on malarial case management and prevention by health services in sub-Saharan Africa predicts 81,000 additional deaths in Nigeria and 769,000 in sub-Saharan Africa in 2020.
In a study of 96,476 participants from the UK Biobank cohort who had their physical activity objectively measured by accelerometer, both the volume of physical activity and its intensity were associated with risk of mortality.
Metformin can promote the regeneration of neural precursor cell populations and improve cognitive function in a preclinical model of cranial radiation and a pilot clinical study of children after cranial radiation and chemotherapy.
The Healthy Nevada Project shows that otherwise invisible disease risk can be revealed through DNA-based screening. Identifying these monogenic risks could be the first step toward a new population health-screening program.
The COVID-19 pandemic has highlighted the crucial importance of antibody surveys in estimating the incidence of SARS-CoV-2 infection at a population level. Studies in Brazil and China address the use of serology to obtain a better estimate of the infection rate.
Injured human donor lungs deemed unsuitable for immediate transplantation may be successfully recovered by connection into the circulation of a porcine host with perfusion and ventilation ex vivo for 24 hours.
Data routinely collected in the emergency department after trauma have the potential to predict those at risk of later PTSD, which shows promise for computational psychiatry.
An analysis of the microbiomes of the Irish Traveller community, which has recently undergone enforced lifestyle changes, increases understanding of the environmental factors that shape the gut microbiome.
