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Human beige adipocyte precursors associated with capillary networks proliferate in response to angiocrines, and when activated in vitro and transplanted into mice, they improve glucose intolerance.
c-Met binds to and phosphorylates PARP1 in cancer cells, thereby reducing PARP1 binding to a PARP inhibitor; c-Met and PARP inhibitor combination therapy shows improved efficacy in preclinical models of breast and lung cancer.
Blocking the enzyme KMO with a small molecule reduces the levels of toxic tryptophan metabolites and reduces multiple extrapancreatic organ failure in a rat model of acute pancreatitis.
Judy Lieberman and colleagues show that intracellular parasites are eradicated by lymphocyte delivery of cytotoxic granule contents—perforin, granulysin and granzymes—into infected cells.