Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 7 Issue 3, March 2006

Skin Langerhans cells provide a first line of protection against pathogens. Merad and colleagues (p 265; News and Views by Palucka and Banchereau, p 223) identify Langerhans cell precursors as Gr-1hi monocytes (red) that migrate into epidermis (blue) and express langerin (green) as they differentiate into Langerhans cells. The image shows a large area of skin surveilled by developing Langerhans cells (red, green). Immunofluorescence by Milena Bogunovic. Art work by Lewis Long.

Volume 7 Issue 3

Subscribe

Editorial

Top of page ⤴

Meeting Report

  • The second Aegean conference on 'Autoimmunity: Mechanisms and Novel Treatments' in September, 2005, discussed topics ranging from animal models of autoimmunity to lymphocyte interactions, as well as molecular influences of disease.

    • Mark J Mamula
    • Donna L Farber
    • George C Tsokos
    Meeting Report
Top of page ⤴

News & Views

  • Precursors of specialized skin dendritic cells called Langerhans cells are derived from specific bone marrow–derived monocyte precursors that migrate to the skin and differentiate into these important immune surveillance cells.

    • A Karolina Palucka
    • Jacques Banchereau
    News & Views

  • Functional and phenotypic distinctions characterize B-1 cells versus B-2 cells. The identification of adult bone marrow cells that give rise exclusively to B-1 B cells support earlier ideas regarding the existence of dedicated B-1 progenitors.

    • Leonore A Herzenberg
    • James W Tung
    News & Views

  • It is unclear whether T cell exhaustion is reversible. A recent Nature paper shows that in vivo blockade of the inhibitory molecule PD-1 can restore the function of exhausted CD8+ T cells during chronic viral infection.

    • Joseph N Blattman
    • Philip D Greenberg
    News & Views

  • Lentiviral Nef protein has many functions in the evasion of host immune defenses. Another 'chink' in the host immune 'armor' has now been exposed by Nef's ability to inhibit immunoglobulin class switching.

    • B Matija Peterlin
    News & Views
Top of page ⤴

Research Highlights

Top of page ⤴

Perspective

Top of page ⤴

Review Article

Top of page ⤴

Article

Top of page ⤴

Search

Advanced search

Quick links