Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 4 Issue 4, April 2003

A pattern of Langerhans cells (green, bottom image) in the style of Andy Warhol (1928–1987). Microarray analysis led Zenke and colleagues to examine the role of Id2 in dendritic cell development. CD8α+ dendritic cells and Langerhans cells were missing in mice that lacked Id2, which may be induced by TGF-β to suppress B lineage genes. Artwork by Lewis Long.

Volume 4 Issue 4

Subscribe

Editorial

Top of page ⤴

Correspondence

Top of page ⤴

Commentary

  • The Midwinter Conference of Immunologists is a popular annual fixture for immunologists to discuss the hot topics in immunology while enjoying the mild weather of the West Coast.

    • Christopher B. Wilson
    • Christel H. Uittenbogaart
    • Diane J. Mathis
    Commentary
Top of page ⤴

News & Views

  • Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance. New data on T cell tolerance in AIRE−/− mice strongly support this hypothsis.

    • Jonathan Sprent
    • Charles D. Surh
    News & Views

  • The transcription factor(s) controlling TReg cell development are not definitely known. The finding that these cells specifically express Foxp3 provides a better understanding of their development and function at the molecular level.

    • Anne O'Garra
    • Paulo Vieira
    News & Views

  • Peptide epitope generation for MHC class I presentation is normally dependent upon proteasome activity. Yet this pathway fails to generate critical HIV epitopes. Instead, the protease TPPII is required for this activity.

    • Carla Herberts
    • Eric Reits
    • Jacques Neefjes
    News & Views

  • Is apoptotic cell death due to the action of caspases? Caspase inhibition can actually encourage death in tumor necrosis factor–induced shock, indicating that caspase activation is not synonymous with apoptotic demise.

    • Jean-Luc Perfettini
    • Guido Kroemer
    News & Views

  • Terminal B cell differentiation requires a massive increase in the biosynthetic capacity to synthesize antibodies in response to infection. New data shows the ER stress response activates and commits B cells to this robust metabolic state.

    • Yanjun Ma
    • Linda M. Hendershot
    News & Views
Top of page ⤴

Round-up

Top of page ⤴

Review Article

Top of page ⤴

Article

Top of page ⤴

Corrigendum

Top of page ⤴

Search

Advanced search

Quick links