Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 1 Issue 5, November 2000

Natural killer cell (blue) contacting a Raji cell (red). Djeu and collegues (page 419) deciphered a PI3 kinase pathway that leads to ERK activation and perforin (green) mobilization in NK cells after they interact with their targets. (see also the News and Views by Perussia, page 372.) Painting by Christopher Cassidy in oil and acrylic on paper (27 x 27 cm).

Volume 1 Issue 5

Subscribe

Editorial

Top of page ⤴

Correspondence

Top of page ⤴

Commentary

  • Translating mouse models into clinical therapies has never been easy. Immunotherapies for cancer also have to contend with an approval process designed for testing drugs. It may be necessary to consider different endpoints and objectives when evaluating the efficacy of these newer approaches.

    • Pramod K. Srivastava
    Commentary
Top of page ⤴

News & Views

  • In a new twist, the cytokine IL-10, if present when leukocytes are activated, can disconnect chemokine receptors from signaling for cell migration. The receptors act as a “sink” for soaking up chemokines, thus providing the perfect decoy.

    • Steven K. Dower
    News & Views

  • B cell maturation is affected by factors found in the microenvironment of the bone marrow. A new tachykinin neuropeptide family member, HK-1, and TSLP both seem to aid the pre-B cell stage.

    • Kenneth Dorshkind
    News & Views

  • Once natural killer cells identify their targets they engage their lysis machinery. Spontaneous, unlike antibody-dependent, cytotoxicity predominantly uses a Ras-independent pathway to accomplish this activation.

    • Bice Perussia
    News & Views

  • Lymphocyte memory—is there a requirement for the continual presence of antigen or not? In a recent issue of Nature an elegant series of genetic manipulations from Maruyama et al. makes a strong case for the persistence of B cell memory in the absence of antigen.

    • Garnett Kelsoe
    News & Views
Top of page ⤴

Round-up

Top of page ⤴

Review Article

Top of page ⤴

Article

Top of page ⤴

Erratum

Top of page ⤴

Search

Advanced search

Quick links