Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Lineage specification and development require a hierarchy of transcription factors. Murre and colleagues have compiled a genome-wide set of cis-acting targets centered on E2A, EBF1 and Foxo1 that govern early B cell development.