Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The genetic culprits that contribute to common diseases remain at large, despite dedicated sleuthing by many laboratories. A new study evaluates the power of genome-wide searches for variants acting in combination, with results that are both unexpected and encouraging.
Sir2 deacetylases are believed to promote the survival and longevity of organisms during times of adversity. A new study shows that activation of Sir2 by small molecules called sirtuin-activating compounds increases neuronal survival in two different models of Huntington disease, possibly opening new avenues for treatment.
Children and young adults with sickle cell anemia at risk for stroke are identified principally by screening for cerebral vasculopathy using transcranial Doppler ultrasonography. Investigators now show how Bayesian networks can generate useful predictive models and highlight relationships between genes and the occurrence of stroke in those with sickle cell anemia.
The first empirical test of an evolutionary theory provides support for a mutational landscape model underlying the process of adaptation. The study shows that it is possible to predict at least the first step in an adaptive walk and also shows the importance of incorporating mutation bias in the fitness effects of mutations.
The X chromosome has traditionally been characterized as a conscientious sister to her derelict brother that is the Y. Beyond dutifully maintaining the family heritage, however, the X has developed its own unique identities. Now, the complete sequence of the human X allows us to appreciate its distinctiveness at an unprecedented resolution.
