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Volume 5 Issue 12, December 2002

Mu-ming Poo and colleagues study signaling pathways involved in the turning of axonal growth cones. They find that myelin-associated glycoprotein (MAG) mediates a repulsive response of the growth cone by signaling through both the Nogo receptor and the p75 neurotrophin receptor. The background image shows a section of monkey dorsal root ganglion, traversed by a myelin-containing neuronal tract. In the foreground image, intracellular calcium rises in a Xenopus axon growth cone as it is repelled by a gradient of MAG. See page 1302.

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