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Zhu et al. develop a deep learning method to precisely infer single-trial neural dynamics from calcium imaging with subframe temporal resolution, which shows improvement over the state-of-the-art methods in capturing high-frequency dynamics and predicting behavior.
The authors report a functional class of channelrhodopsins that are highly selective for K+ over Na+. These light-gated channels, named ‘kalium channelrhodopsins’, enable robust inhibition of mouse cortical neurons with millisecond precision.
The authors present a circuit tracing method, Trans-Seq, which determines the targets of a given neuron type through anterograde tracing combined with single-cell RNA sequencing. Applying Trans-Seq to retinotectal synapses, the authors find a selective connection assembled by Nephronectin.
This study introduces genetically encoded imaging probes that convert intracellular calcium signaling into hemodynamic fMRI responses. The authors show how the probes can be used to map information flow in reward-related brain circuitry in rats.
Neuropixels probes were used to simultaneously record from more than 200 cortical neurons in human participants during neurosurgical procedures. The approach could reveal insights underlying human cognition and pathology.