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This Review discusses two high-throughput techniques—massively parallel reporter assays (MPRAs) and CRISPR screens—focusing on their potential to validate non-coding genetic risk variants in human stem cell models of complex brain disorders.
This review summarizes advances in electrical, optical and microfluidic neural interfaces with characteristics that suggest near-term potential for broad deployment to the neuroscience community.
Gangopadhyay, Chawla et al. examine the neural bases of social decision-making at different processing stages and across humans, non-human primates and rodents. These examinations underscore the importance of the medial prefrontal–amygdala pathways.
Behavioral quantification is changing neuroscience. Pereira et al. provide an overview of the latest advances in motion tracking and behavior prediction and discuss how these methods are used to understand the brain in ways not previously possible.
Chiaradia and Lancaster review applications and limitations of brain organoids, placing them in context with other technologies and describing how these methods are heavily informed by in vivo development.
In this Primer article, Bijsterbosch and colleagues provide an accessible discussion of the challenges faced in analytical representations of functional brain organization and provide clear recommendations to unite a fractionated field.
Aggression is an instinctive behavior supported by hardwired neural circuits. Julieta Lischinsky and Dayu Lin review our current understanding of the neural circuits of aggression across species and their modulation by internal state.
Busche and Hyman review emerging evidence for an interaction between Aβ and tau during Alzheimer’s disease (AD) progression that challenges the classical linear trajectory model and offers a new perspective on AD pathophysiology and therapy.
Keysers et al. show why P values do not differentiate inconclusive null findings from those that provide important evidence for the absence of an effect. They provide a tutorial on how to use Bayesian hypothesis testing to overcome this issue.
Recent studies separately address the neural representation of stimuli and its dynamics in networks that model neural interactions. Ju and Bassett review such recent advances and discuss the integration of neural representations and network models.
The increasing use of cannabis has brought significant attention to cannabis use disorder (CUD) and its neurobiological underpinnings. Here Ferland and Hurd discuss risk factors related to the development of CUD its neurobiological characteristics.
Phase separation is emerging as a versatile means for cellular sub-compartment formation. Chen et al. review recent advances of dense synaptic assembly formation via phase separation and discuss implications of phase separation in synaptic physiology.
