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This Review discusses the current knowledge regarding regulation of epigenetic modifications and mechanisms in the nervous system in response to dynamic signals such as developmental stage, growth factors and synaptic activity.
This review examines evidence supporting diverse roles for epigenetic mechanisms in regulating specific aspects of adult neurogenesis and their implications.
This review discusses the promises and pitfalls of animal models of psychiatric illnesses such as schizophrenia, bipolar disorder and depression. The authors propose guidelines for reporting and interpreting results from such models.
Defects in the cellular homeostatic process of autophagy have been observed in various neurodegenerative disorders. In this Review, Wong and Cuervo highlight the latest literature to discuss different types of autophagic dysfunction in neurodegenerative conditions and compare the interplay between autophagy and other cellular degradation processes.
This review article highlights the recent advances on how amyloid-β (Aβ) peptides can affect synaptic and neuronal circuit function—both in the context of normal brain function and in Alzheimer's disease—and discusses the consequence of aberrant Aβ at neural network level.
