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Depression of AMPA receptor–mediated synaptic currents and impairment of long-term potentiation, triggered by amyloid-β, are the hallmarks of Alzheimer's pathophysiology. These dysfunctions are now linked to upregulated PDZ domain–dependent PTEN translocation to spines, contributing to cognitive deficits in model mice.
Discrimination of neutral from harmful environments is important for survival. But how do salient contextual signals yield persisting memories? A study uncovers a circuit that increases the specificity of hippocampus-based memories.
Analysis of human hippocampus identifies two modules of coexpressed genes that are conserved throughout the human cortex and in mouse hippocampi. These modules are enriched for genetic variants associated with both cognitive phenotypes and neuropsychiatric disorders.
The most complete single-neuron transcriptome database of the mouse visual cortex was performed using a large collection of reporter mouse lines. Results highlight the unmatched neuronal diversity of the cerebral cortex.
A previously unknown mechanism contributes to dysfunction of the neurogenic niche during CNS autoimmunity. Natural killer cells are retained specifically in the subventricular zone in chronic disease, killing stem cells and promoting pathology.
Connections between a specific thalamic structure and the neocortex convey mismatches between internal perceptions and external events. These findings help to define the circuits controlling contextual modulation of visual-motor processing.
