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Donor-acceptor molecules are important components for molecular electronics applications. Here, the authors show that donor-acceptor molecular wires exhibit changes in conductivity under the influence of small changes in the environment.
Ex situ conservation breeding programmes for endangered species are expensive, and not always guaranteed to succeed. Here, Martin-Wintle et al.show that when captive giant pandas are given the opportunity to choose their preferred mate, copulation and birth rates increase significantly.
The nuclear farnesoid X receptor (FXR) is activated by bile acids and influences energy metabolism. Here, the authors report a small molecule inhibitor of FXR, glycine-ß-muricholic acid, which inhibits FXR in the intestine and improves metabolic homeostasis by repressing intestinal ceramide synthesis.
Carcinoma-associated fibroblasts are key components of solid tumours and associated with poor clinical outcome. Here the authors show that the cytokine LIF initiates an epigenetic switch which results in the sustained invasive activity of the tumour cells.
Sepsis patients often develop muscle atrophy that can last for years. Here the authors show in a mouse model that sepsis causes long-term impairment of the satellite cells, affecting mitochondrial function and energy metabolism, and that injection of mesenchymal stem cells restores satellite cell metabolism and muscle regeneration.
The ventral hippocampus connects to the hypothalamus and has been implicated in feeding behaviours. Here, the authors use a combination of optogenetics and DREADD strategies to dissect the underlying circuit, showing that projections from the vHC to the lateral septum work to regulate feeding suppression.
Smoking tobacco is known to alter DNA methylation. Here, the authors show that hypomethylation of smoke-related genes is associated with future increase in lung cancer risk.
The percolation transition has been regarded as model-independent, namely determined by the geometry of a system but otherwise identical for bond or site percolation models. Here, the authors show the violation of this assumption both analytically and numerically for networks with null percolation thresholds.
Graphene nanoribbons have potential applications as nanoscale wires, though experimentally studied ribbons display wide bandgaps. Here, the authors synthesise the narrowest armchair graphene nanoribbon predicted to have metallic behaviour and show these ribbons—5 carbon atoms wide—indeed display almost metallic behaviour.
Single atomic layers of transition metal dichalcogenides are semiconductors with possible applications in spintronics. Here, the authors demonstrate tuning of the spin-orbit splitting in molybdenum tungsten diselenide by altering the alloy’s composition, impacting valley polarization and light emission yield.
Drug seeking behaviour has habitual neural substrates. Here, Murray et al. show that the basolateral amygdala and central nucleus of the amygdala are necessary to recruit and maintain, respectively, the intrastriatal functional transition that underlies cocaine seeking habits.
The surfaces of noble metals possess Shockley states which exhibit Rashba-type spin splitting and spin-momentum locking. Here, the authors use ab initiomethods and photoemission spectroscopy to demonstrate how such Shockley states may be reinterpreted as topologically protected surface states.
Efficient steam generation under solar irradiation is of interest for energy harvesting applications. Here, Bae et al. develop a plasmonic nanofocusing film consisting of metal coated alumina nanowires to efficiently generate solar vapour with an efficiency up to 57% at 20 kWm−2.
Forming a dipole layer at the electron-collecting interface is a proposed method of efficiency enhancement in solar cells. Here, Nam et al.report the use of PEOz as a dipole layer, which increases the work function at the electron-collecting interface within the polymer solar cell leading to an efficiency of 10.7%.
Pertussis toxin is used extensively for perturbing Gαi/o pathways in the study of physiology and disease, but an equivalent inhibitor of Gαq signalling is not currently available to the research community. Here the authors characterize FR900359 as a specific Gq inhibitor and demonstrate its utility to dissect GPCR signalling and its potential to inhibit melanoma cells.
Down syndrome is associated with both central and peripheral nervous system dysfunction. Here, the authors report reduced sympathetic neural innervation in human Down syndrome tissues and a mouse model, and propose a role for RCAN1 trisomy in disrupted NGF receptor trafficking and neurotrophic support.
Oxide materials that undergo a metal to insulator transition under an applied electric field could extend the functionality of electronic devices. Here, the authors induce a phase transition in vanadium dioxide via a titanium dioxide gate, and thus modulate the current flowing through the channel.
In value-based decisions, the longer one fixates on an option, the more likely one is to choose it. Here, the authors compare the performance of people with focal frontal lobe damage in a simple choice task and show that damage to the dorsomedial PFC leads to exaggerated fixation-related value updating.
The amygdala in the medial temporal lobe of the human and non-human primate brain is known to process salient social stimuli and to mediate threat discrimination. Here, Dal Monte et al.show that rhesus monkeys with amygdala lesions have deficits in detecting threat signals and directing attention to the eye region of a conspecific's face.
During neural development thalamocortical axons follow corticofugal projections into the neocortex. Here, using a combination of knock down and rescue experiments, the authors show that Draxin expression in neocortical cells promotes thalamic axon projections from the internal capsule.