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Although epidermal growth factor-like domain 7 (Egfl7) is known to play a pro-angiogenic role in zebrafish, its contribution to brain lymphangiogenesis remains less clear. Here, the authors demonstrate that Egfl7 is dispensable for brain lymphatic endothelial cell specification, but not their migration and proliferation.
Using focused ion beam milling and cryoelectron tomography, Tsuji et al. found actin filaments, with both cofilin-bound and canonical morphologies, within the lumen of human platelet microtubules and reconstituted these structures in vitro.
Here, trace detection of NO2 is achieved with a 2D Schottky-junction Bi2O2Se gas sensor. Simultaneous signals allow for detection in the ppt range, and impedance angle analysis allows for molecular specificity.
Evolution of osmoregulation allowed photosynthetic organisms to transform the whole biosphere. Leveraging high-throughput techniques in the freshwater alga Chlamydomonas reinhardtii, the authors uncover evolutionary conservation and divergence of osmoregulatory pathways within the green lineage.
Transforming model heterotrophs into autotrophs is usually accomplished by engineering one carbon assimilation pathway and/or employing laboratory evolution. Here, the authors report the engineering of cyanobacterial endosymbionts in yeasts to achieve photosynthetic growth, carbon assimilation and natural products production.
The early signalling events following ethylene perception by plants remain incompletely understood. Here the authors show that in the absence of ethylene, rice MHZ3, a known stabilizer of OsEIN2, promotes phosphorylation of OsCTR2 to suppress ethylene signalling.
How aging induces aortic aneurysm and dissection (AAD) remains unclear. Here, the authors show that aging induces miR-1204 to inhibit MYLK, promoting vascular smooth muscle cells to acquire senescence-associated secretory phenotype, resulting in vascular inflammation, and the aggravation of AAD formation.
The Kok cycle describes the mechanism by which water is oxidized through a 5-step process. Here authors use theoretical calculations to reveal how the natural water oxidation catalyst “Mn4CaO5 cluster” is reconstituted after O2 release during photosynthesis and discover the structural isomerism in the first state of Kok’s cycle.
Single cell sequencing often omits certain cell types due to technological constrains. Here the authors report an algorithm called BulkTrajBlend, part of OmicVerse, which fills gaps in single-cell RNA-seq by using Bulk RNAseq data to restore missing cells and improve analysis.
Here the authors introduced a multimodal comparative framework to study the primate hippocampus. Despite expected structural conservation, they also observed functional reconfiguration, reflecting evolutionary changes to brain network integration.
Immune checkpoint blockade could improve the complete cytoreduction rate with standard-of-care neoadjuvant chemotherapy (NACT) in patients with ovarian cancer. Here the authors report the results of a randomized phase II trial of NACT alone or in combination with pembrolizumab (anti-PD1) in patients with advanced high-grade serous carcinoma.
A point mutation in the phosphoribosylpyrophosphate synthetase gene is found to rewire C1 metabolism and thereby enhance colonization capabilities and growth-promoting effects in plants. The effect of this mutation is prevalent across Methylobacterium strains.
Integrating a control interface with a quantum processor as the number of qubits scales is a significant challenge. Here the authors report a cryogenic on-chip microwave pulse generator for superconducting qubits with high degree of controllability, negligible heat load, and a small footprint.
Neural adaptation, crucial for sensory processing, is absent in conventional machine learning models of the visual system. Here the authors show that adding photoreceptor adaptation in these models better predicts retina responses under natural vision.
DNA methylation (DNAm) is a key biomarker of aging, with age-related DNAm changes being well-characterized. Here, the authors show that low-methylated regions (LMRs) bound by PRC2 in embryonic stem cells gain methylation with age in somatic cells, proposing the “PRC2-AgeIndex” as a universal biomarker of cellular aging.
The spontaneous orientation polarization in the emissive layer induced by vacuum deposition should be controlled to improve the efficiency of organic light-emitting diodes. Here, the authors report the control through the delicate design of host molecules, achieving high device operational stability.
Human manganese superoxide dismutase is an oxidoreductase that converts superoxide to molecular oxygen and hydrogen peroxide with proton-coupled electron transfers (PCETs), and has evolved to be highly product inhibited to limit the formation of hydrogen peroxide. Here, the authors use neutron diffraction and X-ray absorption spectroscopy of the product-bound, trivalent, and divalent states of the enzyme to identify the product-inhibited complex and propose a PCET mechanism.
Multiple sclerosis and some other neuroinflammatory diseases are associated with aberrant CD4+ T cell differentiation and regulatory T cell function. Here authors show that the E3 ubiquitin ligase RNF213 is central to both physiological and pathologic CD4+ T cell differentiation, and finetunes IFN-β responses in multiple sclerosis.
The role of lactate in modulating sleep-wake architecture is unclear. Here, the authors show that downregulation of astrocytic MCT4 or orexinergic MCT2 reduces orexinergic activity and wakefulness by impairing lactate export and import, respectively, during wake events.
Exploring the dual-emission mechanism in open-shell nanoclusters with doublet or quartet emissions remains challenging. Here, the authors reveal the origin of dual-quartet phosphorescent emission in the open-shell M1Ag13 (M = Pt, Pd) nanoclusters.