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Since its proposition in 2002, the Division of Chemical Biology in the Department of Chemical Sciences at the National Natural Science Foundation of China has implemented a range of constructive initiatives to break down traditional boundaries between chemistry and biology and to further bridge these two fields, in order to boost the development of chemical biology in China.
Protein glycation has long-been considered a toxic consequence of carbohydrate metabolism. Yet recent evidence demonstrates tight regulation for these non-enzymatic post-translational modifications, pointing to a broader role in cell biology rather than simply serving as a biomarker for toxicity.
Biased signaling gives hormones, probes or drugs distinct functional outcomes via the same receptor. The Biased Signaling Atlas (https://BiasedSignalingAtlas.org) provides a community hub with data and tools to advance this paradigm, which may yield safer and more potent drugs.
