Targets
Target validation using chemical probes - pp195 - 199
Mark E Bunnage, Eugene L Piatnitski Chekler & Lyn H Jones
doi:10.1038/nchembio.1197
Fully profiled chemical probes are essential to support the unbiased interpretation of biological experiments necessary for rigorous preclinical target validation. We believe that by developing a 'chemical probe tool kit', and a framework for its use, chemical biology can have a more central role in identifying targets of potential relevance to disease, avoiding many of the biases that complicate target validation as practiced currently.
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