Recognizing that an analogy can be drawn between steric effects in drug discovery and asymmetric catalysis has led to a powerful technique that can explain and potentially predict the outcome of asymmetric reactions.
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Miller, S. Correlating sterics in catalysis. Nature Chem 4, 344–345 (2012). https://doi.org/10.1038/nchem.1339
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DOI: https://doi.org/10.1038/nchem.1339