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Harnessing DNA repair pathways in genome editing In this Review, Yeh, Richardson and Corn discuss the DNA repair pathways that underlie genome editing and recent improvements and strategies to yield desired genomic alterations in cells and organisms.
In this Review, Caridi et al. discuss actin filaments in the nucleus and the functions of nuclear F-actin in response to DNA double-strand break repair.
In this Review, the authors survey key advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials.
Yao et al. review functions of lncRNAs in controlling chromatin architecture, transcription and nuclear bodies in the nucleus and in modulating mRNA stability, translation and protein modifications in the cytoplasm.
Perez and Lehner summarize recent discoveries regarding epigenetic inheritance across generations and review the molecular mechanisms underlying non-DNA sequence-based transmissions.
This Review describes non-redundant functions of the core transcription factors that mediate the epithelial–mesenchymal transition, and discusses the conflicting results regarding their roles in this process.
Moreno-Layseca et al. discuss how integrins, key receptors that mediate cell adhesion to the extracellular matrix, are endocytosed and recycled to the cell surface to modulate cell and tissue behaviour.
In this Review Article, Chunduri and Storchová discuss how aneuploidy, often seen in cancer cells, affects gene expression, proliferation, proteotoxic stress and genomic stability, and how these changes relate to those in cancer.
Valencia and Kadoch review diverse functions of DNA and histone modifying proteins, and chromatin remodelling complexes in cancer, and discuss how these may be favourably leveraged for therapeutic development.
Joungmok Kim and Kunliang Guan review the landmark discoveries in the mTOR field from the identification of rapamycin to the characterization of mTOR complex components, with an emphasis on the key players mediating amino acid signals to mTOR.
Lee and Schmitt discuss how the classical view of senescence as a static, terminally differentiated state has changed to that of a dynamic, reversible condition with diverse roles in tumour biology.
In this Review, Horng and colleagues cover the emerging roles of cellular metabolism in guiding immune cell activation and cell fate decisions, and discuss how differential metabolic regulation allows for context specificity.
In this Review, Lawrence and Zoncu discuss the central role of the lysosome in cellular metabolism, including in macromolecular catabolism and nutrient recycling, and organelle crosstalk. They highlight the emerging function of the lysosome as a centre for nutrient sensing and metabolic signal transduction.
In this Review, Schermelleh et al. give an overview of current super-resolution microscopy techniques and provide guidance on how best to use them to foster biological discovery.
Brunet and colleagues review emerging rejuvenation strategies that could counteract ageing features, and discuss their mechanisms of action and application against human ageing.
