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Case and Waterman discuss how integrating extracellular-matrix-bound integrins and the actin cytoskeleton into a mechanosensitive molecular clutch transmits actin-cytoskeleton-generated forces to the extracellular matrix through focal adhesions.
Yap and Lecuit review the interplay of E-cadherin-mediated adhesion and actomyosin-based contractility, and discuss the functional effects of their crosstalk at the cellular and tissue level.
Burroughs and DeBerardinis discuss the metabolic pathways that tumour cells employ to promote their survival and proliferation, and present the current approaches to study cancer metabolism in an in vivo setting.
Berninger and colleagues define milestones for in vivo reprogramming and discuss recent developments in reprogramming into pancreatic b-cells and neurons.