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Zhang et al. identify ALKBH7 as the demethylase of mitochondrial pre-tRNAs that regulates nascent mitochondrial RNA processing and translation. ALKBH7 loss impairs mitochondrial functions including fatty acid oxidation, leading to obesity.
Salvi et al. show that GLUT1 is critical for glucose uptake in response to external forces and that ankyrin G is required to retain GLUT1 at sites of E-cadherin force transmission, linking mechanotransduction and glucose uptake.
Garry et al. report that the histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to increase accessibility to core cardiac transcription factors, thus facilitating direct cardiac reprogramming.
Weijts et al. present a model of vasculogenesis in zebrafish whereby endothelial cells form a network of struts, allowing de novo formation of large-diameter blood vessels without a vascular cord or hollowing step.
Using gastruloids and human embryos, Yang et al. demonstrate that aneuploid embryos can still lead to healthy births due to elimination of aneuploid cells by apoptosis in a BMP4-dependent manner.
Recasens-Alvarez et al. model human ribosomopathies and find that apoptosis and cellular stress result from proteotoxic stress that overwhelms the degradation machinery.
Maquat and colleagues report that nonsense-mediated mRNA decay is activated upon loss of the fragile X syndrome protein FMRP in patient-derived induced pluripotent stem cells, which results in defects in neuronal differentiation.
Polarity cues regulate intestinal stem cell fate. Böttcher et al. demonstrate that mouse intestinal stem cells, which express the Wnt/planar cell polarity reporter Flattop, are primed either towards the enteroendocrine or Paneth cell lineage.