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Yang, Zhang et al. identify a non-canonical form of necroptosis driven by nuclear RIPK1-mediated nuclear membrane rupture as a result of ZMPSTE24 deficiency and defective prelamin A processing commonly observed in progeroid disorders.
Duan et al. show that ACE2-dependent and ACE2-independent entry of SARS-COV-2 in epithelial cells versus myeloid cells differentially regulates viral replication and inflammatory responses, thereby contributing to COVID-19 progression and pathology.
Zhu et al. show that loss of WIPI4, as seen in β-propeller protein-associated neurodegeneration, causes ferroptosis independently of autophagy due to an imbalance in phosphatidylethanolamine levels.
Weatherbee, Weberling, Gantner et al. find contrasting requirements for BMP in the anterior signalling centre and pre-implantation epiblast between mice and humans. They further find that NOTCH may be indispensable for human epiblast survival.
Murthy et al. demonstrate that cancer-associated fibroblast-derived acetate regulates polyamine homeostasis via an ACSS2–SP1–SAT1 axis in pancreatic cancer cells, thus enabling cell survival and tumour development under acidosis.
Hoyer et al. establish that selective autophagy mechanisms are needed to remodel the ER and its proteome during in vitro neurogenesis across neuronal subcompartments and decode the substrate selectivity of ER-phagy receptors.
Keber et al. use filtration chromatography and quantitative proteomics of Xenopus egg extracts and show that at least 18% of cytoplasmic proteins are organized in small ~100-nm biomolecular condensates.
Rai et al. report that CAMSAPs can bind to minus ends of microtubules attached to γ-tubulin ring complex (γ-TuRC) and drive microtubule release. They show that CDK5RAP2, but not CLASP2, inhibits CAMSAP-mediated microtubule release from γ-TuRC.
De Jesus et al. describe the redox-mediated regulation of m6A writer methyltransferase 3, which blunts innate immune responses by modification of RNA sensor and editor component mRNAs during the onset of type 1 diabetes in β-cells.
Li, Guo, Wang and colleagues show that the ion channels TMEM63 in Drosophila and TMEM63A in mouse mediate lysosomal mechanosensitivity and modulate lysosomal morphology and function.
Roider, Baertsch et al. present a spatially resolved resource map of the T cell infiltration landscape across and within patients with distinct B cell non-Hodgkin lymphoma entities.
Dragwidge et al. report that the plant endocytic complex, the TSET–TPLATE complex, undergoes biomolecular condensation through interactions with plasma membrane phospholipids and recruits clathrin for endocytosis.
Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the cytoplasm, triggering cGAS–STING activation and innate immune signalling.
Yang et al. identify an essential role for ECSIT in promoting memory CD8+ T cell development by modulating fumarate synthesis and altering TCF-1 activity, thereby impacting host responses during viral infection and tumorigenesis.
Zwick et al. examine longitudinal transcriptional patterns across the entire mouse and human small intestine and find that, in both species, the small intestine comprises five domains of nutrient absorption and three regional stem cell populations.
Xu, Yu, Zhang, Ma, He and colleagues show that SHP-1 inhibition causes increased glycolysis and oxidative phosphorylation through PFKP in leukaemia stem cells, thereby promoting immunosurveillance and chemosensitivity in acute myeloid leukaemia.
Gross et al. show that Atg13 and Atg17 are dispensable for pexophagy during phosphate starvation in yeast. Instead, the metabolite sensor Pho81 binds the Atg1 kinase complex via Atg11 to promote Atg11 phosphorylation by Atg1 and pexophagy.
Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis and underlying tissue regulating placode invagination and Sox9 expression.
Using low-input lipidomics in mouse and human embryos, Zhang, Shui, Li and colleagues find that lipid unsaturation increases with development towards the blastocyst stage. They further show that lipid desaturases contribute to successful embryo implantation.