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Shi et al. show that following adrenergic signalling, PKA phosphorylates AIDA, which in turn interacts with and promotes oxidation of UCP1 to regulate UCP1-dependent adaptive thermogenesis.
Gao et al. show that a secretory variant of E-cadherin encoded by a circular RNA directly activates EGFR and STAT3 signalling, thereby promoting glioma stem cell tumorigenicity.
Lin et al. examine the process of clonal tuning during Flt3L-mediated emergency haematopoiesis, which leads to selective expansion of haematopoietic stem and progenitor cells that are primed to produce type 1 conventional dendritic cells instead of modulating cell fate.
Wei et al. report that in yeast TOR suppresses gametogenic gene expression in mitosis by facilitating RNA decay and facultative heterochromatin assembly. During meiosis, TOR activity is downregulated to permit gametogenesis.
Yeom et al. demonstrate that tumour cell-secreted Dilp8/INSL3 activates Lgr3 signalling and modulates expression of distinct feeding hormones such as NUCB1 and sNPF, thereby inducing anorexia in cancer.
Hakala et al. report that twinfilin dissociates capping proteins from the actin filament barbed ends to promote actin turnover at leading-edge lamellipodia.
Baumgartner et al. identify proteotoxic stress as the underlying cause of the loser status in a cell competition model caused by reduced autophagic, proteasomal flux and accumulation of protein aggregates.
Chumduri, Gurumurthy et al. show that cervical squamous and columnar epithelia derive from two stem cell populations, regulated by opposing Wnt signals, and that a Wnt-repressive environment can induce metaplasia.
Verma et al. report that ALC1 loss confers PARP inhibitor hypersensitivity in homologous recombination-deficient cells through reducing chromatin accessibility.
Posfai, Schell, Janiszewski et al. assess candidate totipotent stem cells with in vitro and in vivo assays of increasing stringency to evaluate their developmental potential and lineage contributions.
Analysing the extra-embryonic mesoderm, Harland et al. show that Eomes influences chromatin accessibility at SCL-bound enhancers for erythropoiesis and enhancers that drive Runx1 expression in the haemogenic endothelium.
Wu et al. show that instead of altering cellular metabolism, asparagine directly binds to LCK and enhances T-cell-receptor signalling, thereby promoting CD8+ T-cell-mediated anti-tumour responses.
Chen et al. perform single-cell analysis and identify transcriptomic remodelling in epithelial cells, macrophages, T cells, fibroblasts and endothelial cells, which together regulate prostate cancer progression.