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Scheibner et al. demonstrate that, during gastrulation in the mouse, epithelial epiblast progenitors upregulate Foxa2 and form the definitive endoderm independently of a full EMT–MET cycle.
Pérez-González et al. explore the mechanical properties of intestinal organoids, and report the existence of distinct mechanical domains and that cells are pulled out of the central crypt along a gradient of increasing tension.
Yang, Xue et al. demonstrate in intestinal organoids that region-specific cell fates drive actomyosin patterns and modulate luminal osmotic forces to coordinate morphogenesis.
Perochon et al. show in Drosophila that gut-derived reactive oxygen species and FGF induce tracheal remodelling after intestinal damage, which in turn promotes intestinal regeneration by activating intestinal stem cells.
Tamamouna, Rahman et al. show that midgut-associated tracheae in Drosophila increase their branching in response to infection, oxidative stress and tumours, driving intestinal regeneration as well as tumour growth.
McGinn et al. show that mechanical stretch in the developing oesophagus promotes the YAP-dependent emergence of a KLF4+ committed basal cell population, revealing how physiological strain triggers the transition to adult homeostasis.
Li et al. identify LIMIT as a lncRNA that modulates MHC-I expression through HSP90 and HSF1, thereby regulating antitumour immune response and the efficacy of immunotherapy.
Sangbum Park, Catherine Matte-Martone and colleagues track Langerhans cells, dendritic epidermal T cells and epithelial basal cells in living mice over time and show that immune cells coordinate with epidermal cells to maintain their positions.
Monserrat et al. report that MSL inactivation suppresses tumour maintenance via enhancing chromosomal instability (CIN). Mechanistically, H4K16ac loss upon MSL inactivation generates under-replicated DNA, leading to CIN.
Phase separation promotes clathrin-mediated endocytosis; Day et al. show that Eps15 and Fcho1 rely on weak, liquid-like interactions to efficiently catalyse endocytosis.
Ponsioen et al. use a FRET‐based ERK biosensor EKAREN5 in patient‐derived organoids to show that EGFR activity amplifies signal transduction efficiency in KRAS or BRAF mutant MAPK pathways.
Yi et al. report that EZH2 exerts a PRC2-independent function in nucleoli, where it bridges FBL and NOP56 to facilitate rRNA methylation and subsequent IRES-dependent translation.
Andrade et al. show that FOXO1 regulates mitochondrial metabolism to stimulate the production of the metabolite S-2HG to promote acquisition of a quiescent endothelial state.
Here Liu et al. show that genome-wide redistribution of methyltransferase-like 3 and 14 transcriptionally promotes the senescence-associated secretory phenotype in an m6A-independent manner.
Esposito et al. show that TGF-β-induced DACT1 forms biomolecular condensates that sequester CK2 to repress Wnt signalling and modulate bone metastasis in cancer.
Gupta et al. show that the membrane repair factor Myoferlin protects against membrane damage of pancreatic cancer lysosomes to sustain enhanced lysosomal function and promote tumour growth.