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Zon and colleagues have performed a reverse genetic screen to target orthologues of 425 human chromatin factors in zebrafish. This allowed them to delineate chromatin regulators that function at distinct stages of primitive and definitive blood formation.
Plath and colleagues survey the global histone modification changes linked to reprogramming. They delineate that the H3K9-methylation-associated protein Cbx3 restricts late events of reprogramming and, in particular, prevents the expression of the pluripotent gene Nanog.
Bakal, Wong and colleagues performed an RNAi screen in Drosophila cells, as well as imaging and systems-level analyses, to identify genes regulating morphological complexity in heterogeneous cell populations. They report that rather than generating novel shapes, most genes control a switch-like transition between distinct morphologies. The authors also extend their findings to mouse and human melanoma cells.
Human embryonic stem cells contain 5-hydroxymethylcytosine (5hmC) generated by the TET enzyme. Jin and colleagues show that TET1 increases 5hmC levels during reprogramming to human inducible pluripotent stem cells, and although this change is critical for optimal epigenetic reprogramming, it does not compromise primed pluripotency.
Maliga and colleagues have produced a library of bacterial artificial chromosome (BAC) transgenes encoding tagged human kinesin and myosin motors, and have generated a collection of BAC-expressing human and mouse cell lines for the study of motor function.