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Keklikoglou et al. report that cytotoxic drugs induce tumour-derived extracellular vesicles that facilitate monocyte expansion through annexin A6 and thus lung metastasis in breast cancer.
Studying blastoderm spreading in zebrafish, Petridou et al. discover that this process is facilitated by tissue fluidization, mediated by a local loss of cell–cell adhesion during mitotic rounding and spatially restricted by Wnt.
Avgustinova et al. report that targeting the H3K9 methyltransferase G9a in skin cancer does not affect single nucleotide variant profiles, but leads to increased tumour aggressiveness after a prolonged latency.
Lafont et al. uncover a checkpoint mediated by TBK1 and IKKε, which phosphorylate RIPK1 in the TNFR1-SC. TBK1 and IKKε recruitment depends on M1 ubiquitylation and NEMO to restrict TNF-induced cell death.
Hara et al. find that the recruitment of the KMN kinetochore protein network is mainly dependent on the CENP-T pathway and promoted by Cdk1-mediated phosphorylation of CENP-T in chicken DT40 cells.
Michel et al. report unique localization of non-canonical BAF to CTCF sites and promoters, which confers synthetic lethality in canonical BAF-perturbed synovial sarcoma and malignant rhabdoid tumour cells.
Jung et al demonstrate that TMEM9 facilitates vacuolar-ATPase assembly to enhance vesicular acidification, thereby promoting activation of Wnt signalling and development of colorectal cancer.
Lock et al. identify reticular adhesion complexes that maintain cell–extracellular-matrix attachments during cell division. Reticular adhesions transmit spatial memory between cell generations, mediated by αvβ5 integrin and PtdIns(4,5)P2.
Cigliola et al. show that β-cell loss activates insulin production in a small number of α-cells and that insulin and Hedgehog signalling actively maintain and enforce the α-cell fate.
Ying et al. show that oncogenic PI3K–AKT activation, through the suppression of SH3RF1, induces epidermal differentiation, inhibits progenitor self-renewal and prevents tumour initiation.
Jung et al. demonstrate that loss of CRAD impairs F-actin polymerization and disrupts the cadherin–catenin–actin complex, thereby hyperactivating Wnt signalling and promoting mucinous intestinal tumorigenesis.
Using time-lapse microscopy and transcriptome analysis of the post-implantation mouse embryo, Christodoulou et al. show that cavity fusion occurs through the formation and polarized resolution of multiple, multicellular three-dimensional rosettes.
Basnet et al. discover that in vitro SSNA1 forms fibrils that attach along protofilaments and guide these to grow away from microtubules, forming templates for branched microtubules. SSNA1 mutations that perturb this process lead to defective axon branching in primary neurons.
Wang et al. show that mitochondrial stress alters paraspeckle number and morphology through regulating the transcription and processing of lncRNA NEAT1, retaining mRNAs of mitochondrial proteins in paraspeckles.
Fort et al. identify CYRI as a conserved negative modulator of Scar–WAVE-induced lamellipodia by interacting directly with active Rac1, thereby conferring pseudopod plasticity and dynamics during motility.
Zhu et al. show that the long noncoding RNA lncGata6 enhances Wnt signalling in intestinal stem cells by recruiting the NURF remodelling complex onto the Ehf promoter and initiating its transcription, which triggers expression of Lgr4/5.
Barnes et al. report a dynamic and reciprocal crosstalk between tissue tension and glycocalyx bulkiness that promotes a mesenchymal, stem-like phenotype in GBM.
Lenos et al. report that the spatiotemporal regulation of stem cell functionality is not intrinsically determined but environmentally defined during tumour growth and drug response in colon cancer.
Liu et al. show that reduced m6A mRNA methylation in endometrial cancer is oncogenic. Mechanistically, the AKT pathway is activated in these tumours due to altered expression of AKT regulators carrying m6A on their transcripts.