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Chia et al. show that developmental arrest after human nuclear transfer is associated with genetic instability, including DNA damage, which occurs during DNA replication and is influenced by the developmental origin of the transferred nucleus.
Lilja et al. find that SHANK proteins inhibit the signalling of Ras and Rap G-proteins by restricting their availability at the plasma membrane. This leads to restricted integrin activation, affecting cell spreading, migration and invasion.
Park et al. study individual cell dynamics during mouse wound re-epithelialization in real time and reveal a finely orchestrated interplay between epidermal migration, directional division and differentiation.
Yang and colleagues report that the LINK-A lncRNA binds to the PIP3 phospholipid, leading to enhanced AKT signalling, tumorigenesis and resistance to AKT inhibitors.
Asada et al. examine differential effects of CXCL12 and SCF expression by perivascular bone marrow niche cells, such as arteriolar NG2+ vascular smooth muscle cells and sinusoidal LepR+ cells, on haematopoietic stem cell maintenance and mobilization.
Liu et al. identify an interstitial progenitor cell, characterized by Twist2 expression, that is highly myogenic, forms type IIb/x myofibres and contributes to regeneration in adult skeletal muscle.
Langen et al. identify a third capillary endothelial cell subtype, termed type E, that supports embryonic and early postnatal bone formation, and show that endothelial integrin β1 and laminin α5 are required for bone angiogenesis and osteogenesis.
Cancer-associated fibroblasts (CAFs) promote metastasis by creating tracks for cancer cell migration. Labernadie et al. now show that heterotypic adhesions between E-cadherin on cancer cells and N-cadherin on CAFs transmit forces to drive invasion.
Fu et al. define a heterogeneous population of MaSC subsets based on the expression of LGR5 and TSPAN8, with varying anatomical locations in the mouse mammary ductal tree, in vivo repopulating abilities, cell cycle status and molecular signatures.
Liu et al. show that G1 cyclins and their cyclin-dependent kinases regulate the pluripotent state by driving phosphorylation of Nanog, Oct4 and Sox2, thereby identifying a direct connection between G1 cyclins and pluripotency factors.
Li et al. show that ROR1–HER3 receptor tyrosine kinase signalling in breast cancer cells inhibits the MST1/2 Hippo pathway kinases through a lncRNA termed MAYA. The resulting activation of YAP promotes osteoclast differentiation for bone metastasis.
Using structured illumination microscopy, Beach et al. and Hu et al. visualize the assembly of myosin II filaments in cells, describing a filament-partitioning mechanism, and long-range self-organization of filaments, respectively.
Aguirre-Ghiso and colleagues report that hypoxia in the primary tumour microenvironment leads to upregulation of a dormancy signature in the tumour cells that persists after their dissemination to distant sites, permitting them to evade therapy.
Maillo et al. show that in hepatocytes ER stress upregulates CPEB4 through the UPR and circadian clock, leading to CPEB4-mediated translation for mitochondrial and ER homeostasis. CPEB4 loss leads to ageing- and high fat diet-induced liver steatosis.