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Saheki and colleagues show that extended synaptotagmins (E-Syts), ER proteins that function as tethers to the plasma membrane, can transfer lipids between bilayers in a Ca2+- and SMP-domain-dependent manner, thus regulating plasma membrane lipid homeostasis.
Gundersen and colleagues report that FAK, talin and PIPKIγ maintain the active conformation of integrin that is internalized in Rab11 recycling endosomes, to polarize focal adhesion assembly for directed cell migration.
Dai and colleagues reveal that proteotoxic stress causes JNK-mediated disintegration of the mTORC1 complexes, whereas heat shock factor 1 (HSF1) counteracts this response to promote stress resistance and growth.
Liu et al. show that, in response to energy stress, the NBR2 long non-coding RNA binds AMPK and promotes its activity to reduce cancer cell proliferation. Conversely, loss of NBR2 inhibits AMPK, leading to mTOR activation and tumour growth.
Zhao and colleagues model choroid plexus tumorigenesis in mice, and report that Notch-mediated suppression of multiciliate differentiation promotes tumour initiation from roof plate progenitor cells in response to epithelium-derived Shh signalling.
Centrioles are formed from a nine-fold symmetric cartwheel structure. Using mutants of the cartwheel protein SAS-6, which alters cartwheel symmetry, Hirono, Gönczy, Steinmetz and colleagues show that the microtubule wall also determines centriole shape.
Graf and colleagues find that B cells exposed to a pulse of C/EBPα and the Yamanaka factors convert into elite-type cells that rapidly and efficiently reprogram into iPSCs, in a process that involves upregulation of Lsd1, Brd4 and Klf4.
Using mathematical simulations and a FRET tension sensor inserted into the microtubule-binding complex Ndc80, Suzuki and colleagues obtain insights into how force is generated at the budding yeast kinetochore.
Following autophagy induction, lysosomes move to the perinuclear region. Xu and colleagues delineate a pathway involving PtdIns(3,5)P2-mediated activation of the TRPML1 channel and the Ca2+ sensor ALG-2 in this process.
Receptor-interacting protein kinase 3 (RIPK3) is a key regulator of necroptosis. Seo et al. show that the E3 ligase CHIP mediates ubiquitylation and lysosomal degradation of RIPK3, thus regulating both necrosome formation and necroptosis.
Durocher and colleagues find that in budding yeast, the movement of chromosomes induced by DNA breaks is due to the loss of attachment of kinetochores to spindle pole bodies and of telomeres to the nuclear periphery, and may promote checkpoint arrest.
DNA resection is the first step of double-strand break repair by homologous recombination. Broderick et al. find that EXD2 plays a key role in this process by acting as an essential cofactor for the MRN complex.
Nerlov and colleagues show that expression of mKitL by cortical vascular endothelial cells is important for DN1 progenitor maintenance, whereas expression of mKitL by cortical thymic epithelial cells is required for maintaining DN2 progenitor cells.
Lecuit and colleagues show that, depending on its interaction partner, the G-protein-coupled receptor Smog regulates myosin II activation in different locations during Drosophila morphogenesis.
Yang and colleagues identify a lncRNA that controls HIF1α signalling to stabilize HIF1α under normoxic conditions, and promotes breast cancer tumorigenesis.