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Meng et al. show that ZBTB43 alters Z-DNA structures to prevent deleterious double-strand breaks and promote DNA methylation at purine–pyrimidine repeats in the mouse germ line.
Zhu et al. identify Dapl1 as a negative regulator of CD8+ T cell responses by modulating NFATc2 activation and T cell exhaustion, leading to dysregulated control of chronic infection and cancer.
Williams et al. report that, upon TORC1 inhibition in yeast, mRNA of the chaperone protein ADC17 is localized to cortical actin patches where its translation is enhanced upon stress.
Ouyang et al. show that the RNA helicase ZNFX-1 preserves heritable RNAi by maintaining a pool of small RNA-targeted transcripts in perinuclear condensates of the Caenorhabditiselegans germline, which serve as templates for small-RNA amplification in the next generation.
Haque et al. report that the Hedgehog pathway kinesin KIF7 binds the transcription factor GLI via electrostatic coiled-coil interactions, and synergy between KIF7 and GLI underlies the recruitment of both proteins to microtubules and the cilium tip.
Zhang et al. use single-cell RNA sequencing and functional analyses to describe the hyaluronic acid–GPRC5C signalling axis as an essential component controlling the state of dormancy for human and mouse haematopoietic stem cells.
Two side-by-side papers report that H3K27me3 deposited by polycomb repressive complex 2 represents an epigenetic barrier that restricts naive human pluripotent cell differentiation into alternative lineages including trophoblasts.
Rothová et al. deconstruct endodermal cell fate trajectories through single-cell transcriptomics and identify the central intermediate population transdifferentiating from an extra-embryonic to an embryonic identity.
Savini et al. report that lysosomal lipolysis in peripheral adipose depots produces polyunsaturated fatty acids (PUFAs). PUFAs and the lipid chaperone LBP-3 induce a nuclear hormone receptor, neuropeptide-mediated cascade in neurons to extend lifespan.
Andreu et al. show that force regulates nucleocytoplasmic transport by weakening the permeability barrier of nuclear pore complexes, affecting passive and facilitated diffusion in different ways.
Thomas, Egan et al. report that hexokinase 2 localizes to the nucleus of leukaemic and normal haematopoietic cells to maintain stemness by interacting with nuclear proteins and modulating chromatin accessibility independently of its kinase activity.
Verginadis et al. show that ATF4 regulates Col1a1 expression and collagen biosynthesis in perivascular cancer-associated fibroblasts, thereby supporting angiogenesis and progression in melanoma and pancreatic cancer.
Cao et al. show that miR-122 encapsulated in breast cancer-derived extracellular vesicles targets PKM to downregulate β-cell insulin secretion, leading to dysregulated glucose homeostasis and enhanced tumour growth.
Two side-by-side papers report that H3K27me3 deposited by polycomb repressive complex 2 represents an epigenetic barrier that restricts naïve human pluripotent cell differentiation into alternative lineages including trophoblasts.
Chan et al. report that 3′ UTR splicing is widespread and enhanced across different cancer types and is associated with more advanced tumour progression.
Wu et al. optimized the m6A mapping method for ultralow-input materials and characterized the transcriptome-wide landscape of m6A methylation in mouse oocytes and early embryos.
Zeziulia et al. identify the proton-activated Cl− channel ASOR/TMEM206 as necessary for shrinkage of macropinosomes, which is needed for downstream sorting events.
Eroglu et al. report that epicardial progenitor cells expressing the tight junction protein CLDN6 give rise to cardiomyocytes to contribute to cardiac muscle regeneration following heart injury in salamanders.
Blassberg et al. report that SOX2 levels determine the chromatin occupancy of TCF/β-catenin, thus orchestrating the WNT response and epiblast progenitor fate.
Gong et al. report that ETV2 functions as a pioneer factor that remodels chromatin and regulates endothelial genes, thus providing a mechanism of endothelial development with potential therapeutic applications.