Nature Biotechnology

Volume 20 Issue 12, December 2002

Microglial cells, implicated in multiple sclerosis (MS), superimposed on an image of a demyelinated lesion in an animal model of MS. On page 1215, Geiger and colleagues describe T cells engineered to tackle MS-like autoimmune disease. (Microglial cells © Photo Researchers; histology image courtesy Raymond A. Sobel).

Volume 20 Issue 12

Editorial

Pride comes before a fall (and a bloodbath)

Editorial 01 Dec 2002

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Business and Regulatory News

European Commission rethinks biotech patents

Peter Mitchell
Business and Regulatory News 01 Dec 2002
Surprise US election results may boost biotech

Jeffrey L. Fox
Business and Regulatory News 01 Dec 2002
Japanese council urges reform of funding system

Robert Triendl
Business and Regulatory News 01 Dec 2002
Tissue engineering firms go under

Aaron Bouchie
Business and Regulatory News 01 Dec 2002
Agbiotech issues climb US political agenda

Jeffrey L. Fox
Business and Regulatory News 01 Dec 2002
Study critiques corporate control of trials

Eric Niiler
Business and Regulatory News 01 Dec 2002
In Brief

Business and Regulatory News 01 Dec 2002

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Commentary

Shares in the human genome—the future of patenting DNA

Sandy M. Thomas
Michael M. Hopkins
Max Brady
Commentary 01 Dec 2002
Antibody evolution beyond Nature

Carl A.K. Borrebaeck
Mats Ohlin
Commentary 01 Dec 2002

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Fools Corner

The margin of safety

Tom Jacobs
Fools Corner 01 Dec 2002

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Book Review

Step back from the trees

Larry E. Gundersen
Book Review 01 Dec 2002

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Correspondence

Divergent perspectives on GM food

Roger Beachy
Jeffrey L. Bennetzen
Wayne Parrott
Correspondence 01 Dec 2002
Divergent perspectives on GM food - Letter 2

Alex Avery
Correspondence 01 Dec 2002
Reply to 'Divergent perspectives on GM food'

Correspondence 01 Dec 2002
Expectations and reality in gene repair

Kyonggeun Yoon
Olga Igoucheva
Vitali Alexeev
Correspondence 01 Dec 2002

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Feature

Reconstructing pharmaceutical instinct

Integration of variegated pharmaceutical data sets is a highly desirable goal, but attaining it requires more than placing all the data on the same server.

John Hodgson
Feature 01 Dec 2002

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News & Views

Killers come to the rescue

T cells genetically modified to express a peptide–MHC complex, normally involved in the induction of autoimmunity, can kill pathogenic T cells and inhibit autoimmune disease.

Marie Wahren-Herlenius
Vijay K. Kuchroo
News & Views 01 Dec 2002
Tumor reactive T cells get a boost

Stimulating engineered T cells with a powerful immunogen enhances their ability to kill tumor cells.

Drew M. Pardoll
News & Views 01 Dec 2002
Signposts on the neural path

New studies are elucidating the genetic pathways that control the in vitro differentiation of embryonic stem cells into neural cells.

David Gottlieb
News & Views 01 Dec 2002
It takes three to tango

The recently determined high-resolution crystal structure of the bacterial multidrug resistance transporter AcrB brings us one step closer to the design of more effective therapeutic agents.

Olga Lomovskaya
Helen I. Zgurskaya
Hiroshi Nikaido
News & Views 01 Dec 2002

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News in Brief

In Brief

News in Brief 01 Dec 2002

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Article

Targeting autoantigen-specific T cells and suppression of autoimmune encephalomyelitis with receptor-modified T lymphocytes

M. Divya Jyothi
Richard A. Flavell
Terrence L. Geiger
Article 11 Nov 2002
Dual-specific T cells combine proliferation and antitumor activity

Michael H. Kershaw
Jennifer A. Westwood
Patrick Hwu
Article 04 Nov 2002
Systemically delivered antisense oligomers upregulate gene expression in mouse tissues

Peter Sazani
Federica Gemignani
Ryszard Kole
Article 11 Nov 2002
Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice

Vincent O. Mallet
Claudia Mitchell
Hélène Gilgenkrantz
Article 18 Nov 2002
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation

Jerôme Aubert
Hannah Dunstan
Austin Smith
Article 25 Nov 2002
Growth factor engineering by degenerate homoduplex gene family recombination

Wayne M. Coco
Lance P. Encell
Daniel J. Monticello
Article 11 Nov 2002
Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently

Jon E. Ness
Seran Kim
Jeremy Minshull
Article 11 Nov 2002
Starch content and yield increase as a result of altering adenylate pools in transgenic plants

Babette Regierer
Alisdair R. Fernie
Jens Kossmann
Article 11 Nov 2002

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Technical Report

BMP4 initiates human embryonic stem cell differentiation to trophoblast

Ren-He Xu
Xin Chen
James A. Thomson
Technical Report 11 Nov 2002
Boosting heterologous protein production in transgenic dicotyledonous seeds using Phaseolus vulgaris regulatory sequences

Geert De Jaeger
Stanley Scheffer
Geert Angenon
Technical Report 04 Nov 2002

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Patents

Patent searches for genetic sequences: How to retrieve relevant records from patented sequence databases

Results from current homology-based search tools, designed to locate biologically relevant sequences, present a level of uncertainty from an intellectual property standpoint.

Guillaume Dufresne
László Takács
Manuel Duval
Patents 01 Dec 2002
Recent patents in antibacterials

Patents 01 Dec 2002

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People

People

People 01 Dec 2002

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New on the Market

Centrifuges and Antibodies

New on the Market 01 Dec 2002

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Careers and Recruitment

Calling for entrepreneurs: London

Three London colleges are seeking to spin off companies from its successful research.

Paul Smaglik
Careers and Recruitment 01 Dec 2002

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