Reviews & Analysis

Engineering and manipulating phase-separated liquid organelles is the latest frontier in the quest to mimic and interrogate living systems at the molecular level.

Advances in deep brain stimulation technologies are poised to improve outcomes in the clinic.

Anikeeva and colleagues review the state of the art in technologies that enable discoveries of brain function and the development of novel therapeutic approaches.

From unbiased mutagenesis to precision modification, in genes or whole genomes, researchers have a panoply of tools to direct evolution.

Development of next-generation crops will be enabled by combining state-of-the-art technologies with speed breeding.

Bailey and Maus discuss cutting-edge developments in engineering immune cells towards expanding the reach and efficacy of adoptive cell therapies in cancer and beyond.

Heikenfeld et al. survey the range of biochemical analytes that can be sensed in dermal interstitial fluid, saliva and sweat, and outline criteria for tailoring sensor design to address the right analyte in the right body site for the right disease or wellness application.

Assessing progress towards designing reliable wearable biosensors reveals the challenges remaining before the promise of clinical translation can be realized.

Pere Santamaria and Pau Serra review the state of the art in antigen-specific therapies for autoimmune disease, discussing mechanism of action and clinical efficacy of each strategy.