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By casting large-language-model-based dialogue-agent behaviour in terms of role play, it is possible to describe dialogue-agent behaviour such as (apparent) deception and (apparent) self-awareness without misleadingly ascribing human characteristics to the models.
This Perspective reviews successful applications of functional magnetic resonance imaging (fMRI) and presents a case for fMRI as a central hub on which to integrate the dispersed subfields of systems, cognitive, computational and clinical neuroscience.
The mechanisms by which mitochondria are transferred between cells and how intercellular mitochondria transfer regulates physiological processes and disease pathogenesis are discussed.
Technical developments and large collaborative research networks in neurogenomics promise rapid progress in neuroscience, but translation of results from model systems to human brains is limited by sample availability, technical challenges and ethical issues.
Although the catalogue of human protein-coding genes is nearing completion, the number of non-coding RNA genes remains highly uncertain, and for all genes much work remains to be done to understand their functions.
The challenges and opportunities for the design of field-effect transistors are discussed and a vision of future transistors and potential innovation opportunities is provided.
The rationale behind chimaeric antigen receptor T cell therapy is reviewed, and current challenges in oncology, preliminary reports in noncancerous diseases and relevant emerging technologies are discussed.
This Perspective reviews advances in the understanding of the intersection between the DNA damage response and the response to immune checkpoint blockade therapy, and discusses how developments in the field could lead to improved anti-cancer therapies.
This Perspective reviews the utility and interpretation of circulating tumour DNA for the detection of residual and recurrent cancers and provides recommendations regarding its clinical application for a variety of solid tumours.
An analysis of chemical processes to immobilize lead from perovskite solar cells is presented, highlighting the need for a standard lead-leakage test and mathematical model to reliably evaluate the potential environmental risk of perovskite optoelectronics.
This review discusses generalist medical artificial intelligence, identifying potential applications and setting out specific technical capabilities and training datasets necessary to enable them, as well as highlighting challenges to its implementation.
This Perspective reviews the evidence for and against the existence of a fetal microbiome and concludes that detected microbial signals are most likely the result of contamination, suggesting that the ‘sterile womb’ hypothesis is correct.
