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Stimulation of pain-sensing neurons, which can be achieved in mice by the ingestion of capsaicin, promotes the migration of haematopoietic stem cells from the bone marrow into the blood.
Chromothripsis—a process during which chromosomes are ‘shattered’—drives the evolution of gene amplification and subsequent drug resistance in cancer cells.
Cryo-electron microscopy structures of the nucleosome-bound NSD2 and NSD3 histone methyltransferases reveal the molecular basis of their histone modification activity, and show how mutations in these proteins can lead to oncogenesis.
The net PKA activities in each class of spiny projection neuron in the nucleus accumbens of the mouse are dichotomously modulated by asynchronous positive and negative dopamine signals during different phases of learning.
A class of compounds with a dual mechanism of action—direct targeting of IspH and stimulation of cytotoxic γδ T cells to enhance pathogen clearance—are active against multidrug-resistant bacteria.
Ancient DNA reveals genetic differences between stone-tool users and people associated with ceramic technology in the Caribbean and provides substantially lower estimates of population sizes in the region before European contact.
A chip-scale platform is developed for the conversion of a single microwave excitation of a superconducting qubit into optical photons, with potential uses in quantum computer networks.
A reinforcement-learning algorithm that combines a tree-based search with a learned model achieves superhuman performance in high-performance planning and visually complex domains, without any knowledge of their underlying dynamics.
By combining the use of photoswitchable photoinitators and intersecting light beams, objects and complex systems can be produced rapidly with higher definition than is possible using state-of-the art macroscopic volumetric methods.
Expression of the Epstein–Barr virus protein LMP1 in B cells increases expression of—and promotes T cell responses to—tumour-associated antigens, delineating a mechanism of infection-induced anti-tumour immunity, which could inform immune-based approaches to cancer treatment.
Topological plasmonic spin textures are excited by shining light on a structured silver film, and imaging defines how these quasiparticle field and spin textures evolve on the nanometre and femtosecond scales.
Rats learning to solve a succession of odour-sequence problems developed an orbitofrontal cortical representation that reflected the structure—or schema—common across problems.
In real-world spatial navigation and observation tasks, oscillatory activity in the human brain encodes representations of self and others, with oscillatory power increasing at locations near the boundaries of the room.
RANK promotes the hormone-mediated development of thymic regulatory T cells during pregnancy; loss of RANK is associated with impaired maturation of maternal regulatory T cells, leading to fetal loss and the development of gestational diabetes.
Analyses of virological and surveillance data in France show that a substantial proportion of symptomatic cases of COVID-19 have remained undetected and that easily accessible and efficient testing is required to control the pandemic.
An analysis of 16 types of facial expression in thousands of contexts in millions of videos revealed fine-grained patterns in human facial expression that are preserved across the modern world.
Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.
Inhibitors of mitochondrial transcription that target human mitochondrial RNA polymerase provide a chemical biology tool for studying the role of mitochondrial DNA expression in a wide range of pathologies.